Breast Implant Illness Tests 

There is no definitive test to prove that implants are the cause of illness. The body’s manifestation of symptoms is the best indication of a reaction. However, the following list of tests have been used to explore symptoms that may arise after implantation and may show abnormal results. It’s important to note that many symptomatic patients still have lab work that appears relatively normal.

Lab Work:

  • Female Comprehensive Hormone Panel:
    • CMP (checks glucose, electrolytes, kidney and liver function)
    • CBC + Lipids (checks red blood cells, white blood cells, and platelets for anemia, infection, bruising, and weakness)
    • TSH, Free T3, Free T4, Reverse T3, TPO Ab and TG Ab (Thyroid)
    • Cortisol (adrenals)
    • Hormones: DHEA-S, Estradiol, Estrogen, Progesterone, Pregnenolone, Testosterone Free and Total, Sex Hormone Binding Globulin (SHBG). It is best to get these checked between days 15-20 of your cycle. Day one of your cycle is the first day your bleeding begins.
  • ANA (autoimmune marker)
  • CRP, ESR (inflammation)
  • Vitamin D, 25 hydroxy (vitamin D deficiency)
  • Homocysteine, B-12 and folate
  • Iron and ferritin
  • NK Cells and CD57 (immunodeficiency)
  • APA Assay (abnormal immune system response with fibromyalgia)
  • Check for viruses and co-infections (viral and bacterial load):
    • Epstein Bar Virus (EBV), Mycoplasma, H. pylori, Coxsackie A, Coxsackie B, HSV-I, HSV-II, HHV 6, Cytomegalovirus (CMV), Varicella Zoster, and lyme.
    • Any virus has the capacity to remain in the body in the latent form throughout our lives and may reactivate when the body is stressed or immune function is compromised. Breast implants serve as a trigger for dormant viruses, reactivating chronic viral infections.
  • Candida, IgM and IgG (yeast/fungi)
    • Ig = immunoglobulin or antibody. IgM indicates a current and active infection; IgG shows a past infection.
  • Parasites, leaky gut, and dysbiosis
  • Temperature for thyroid/adrenals:
    • Check your body temperature 3 hours, 6 hours and 9 hours under the tongue after waking and get the average of the three temperatures. A healthy body has an average daily temperature of 37° C (98.6° F). Low and fluctuating levels may indicate thyroid/adrenal problems. See body temperature and metabolism and the metabolic temperature graph for more info.
  • Liver function tests
  • Ultrasound or MRI (recommended to be done without contrast to avoid gadolinium toxicity) – beware of false reads, many times they do not show gel bleed or rupture when there actually is. Dr. Pierre Blais, chemist and implant analysis expert, writes on gadolinium contraindication for implant users.
  • Please note, mammography can contribute to ruptures and breast swelling. It is no longer advised for usage with breast implants in the breast implant awareness groups. See Breast Implant Adverse Events During Mammography for a study by FDA scientists indicating that silicone or saline implants sometimes rupture when women undergo mammograms. There have also been cases reported in the BIA-ALCL FB Support Group where mammograms have triggered breast swelling and led to BIA-ALCL diagnoses

Toxicity Testing:

Silicone toxicity, heavy metal toxicity, chemical toxicity, and biotoxicity have been related to breast implants.

Breast implants experience wear, tear, and degradation. Chemist, Dr. Pierre Blais, states, “the devices act as time release systems for pharmacologically active compounds.” Natural shell degradation through oxidation, enzymatic degradation, physical degradation, diffusion of gel bleed, absorption of proteins, pH and acidity, biofilm formation, etc. affect the stability and integrity of the polymeric implant surfaces. They are in the body at 98.6℉, which may increase with exercise, use of saunas, etc. Below are some texts to investigate the toxicity aspect.

  • Silicone Toxicity Tests
    • Silicone Hypersensitivity Panel (betterlabtestsnow.com, done through elisaact.com see catalog)
    • Silicon Serum/Plasma (NMS Labs – measures the presence of silicon, not silicone or silica)
    • Schirmer’s eye test (dryness – sign of silicone toxicity).
      • Rheumatologist and silicone toxicity expert, Dr. Arthur Brawer, states: “As an example, at least 75% of symptomatic silicone recipients have markedly dry eyes and dry mouth, and Schirmer tests are quite abnormal in these patients. However, their biopsies of salivary tissues are completely normal, because this ailment is likely due to dysfunction of the receptor for acetylcholine (which normally stimulates these glands).”
      • Case Study: Can breast implants be responsible for dry eye? (2014)
  • Heavy Metals
    • Hair, sweat, nails, saliva, blood, urine, or capsule tissue.
    • Due to toxins often being deposited in tissue, blood test levels may be best for acute, relatively high dose exposure, but are usually not so appropriate when exposure is chronic and low level.
    • Hair trace mineral analysis (HTMA) is a popular test for showing mineral deficiencies and heavy metal levels from chronic toxic exposure.
    • List of Heavy Metals used in manufacturing breast implants
  • Biotoxin/Mold
    • Visual Contrast Sensitivity (VCS) Test – free online (vcstest.com)
    • Lab Work: Alpha MSH, C4a, VEGF, ADH/Osmolality, TGF Beta-1, MMP-9, ACTH/Cortisol, Leptin, VIP, and optionally you can test for specific HLA Drs to check for genetic susceptibility to mold sensitivity. For more information on these tests, see here and here. If you are having gut issues you can do the Candida IgM/IgG test. Additionally, mold can also affect the sinus cavities and you can ask to be tested for MARCONS/staph in the nares.
    • MRI+NeuroQuant test has shown mold toxicity in a lady in the breast implant illness groups. This test can show changes in the brain caused by toxins or PTSD and is excellent for showing inflammation in the brain from mold. To read more about the NeuroQuant test in relation to mold, see here.
    • Other tests: Urine Mycotoxin Tests (mycotoxins are metabolites produced by fungi, such as mold – see here for a study on mycotoxins), Comprehensive Stool Test, and a Mold Sensitivity Panel (Elisa/ACT).
    • If you do test positive for mold, find a naturopathic doctor or functional medicine doctor that specializes in the mold/Dr. Shoemaker protocol. See here for a list of websites that have mold doctor lists. Resources for recovery from mold: survivingmold.com, survivingtoxicmold.com, Dr. Shoemaker 11 Step Treatment Protocol, and biotoxinjourney.com.
  • Chemicals
    • Environmental chemicals sensitivity test (ELISA/ACT)
    • Toxic Effect chemical quantity tests (Genova)
    • Xylene and Toluene urine tests.
      • Genova Triad Blood and Urine Profile found xylene in the lab results of a woman with breast implants. Xylene is listed as an ingredient in the FDA SSEDs for breast implants.
    • Previous research from Dr. William J. Rhea and his book Chemical Sensitivity: Clinical Manifestations, Volume 3 found that in “some cases, biopsy of the breast adjacent to the capsule revealed elevated levels of benzene, toluene, styrene, xylene, etc” (pg. 1273).
  • Genetics
    • MTHFR
      • 23 and Me – DNA genetic testing and analysis, checks for MTHFR and much more. Afterwards you can upload the data to other websites, such as Geneticgenie.orgKnowyourgenetics.com, and Nutrahacker.com to see how you can support your particular genetic variants with food and supplements. There is also snpedia.com where you can explore specific gene variants connected with certain diseases. 23 and Me comes highly recommended. A majority of the women in the breast implant illness groups test positive for MTHFR and this affects the body’s abilities to detox.
    • HLA-B27, HLA-DR52, HLA-DR53 (Red Cross)
  • Other
    • Metabolic analysis profile (Genova)
    • Poryphyrins urine test (Genova)

Dr. Arthur Brawer is a rheumatologist and silicone toxicity expert who has done over two decades of research on breast implant recipients and states: “once silicone recipients became ill from their implants, they became intolerant to small amounts of toxicity coming from elsewhere, the latter of which did not cause any problems prior to implantation (room freshness, hairsprays, perfumes, deodorants, cleansers, exhaust fumes, cigarette smoke, certain foods, etc.). As you are already aware these phenomena include headaches, nausea, dizziness, etc. whenever ailing recipients came in contact with these items.”

Notes:

1. CD30 ALCL Testing

If you have implants and experience unilateral swelling, seroma, a breast mass, or even capsular contracture, it’s important to advocate for CD30 testing to rule out BIA-ALCL. This is especially relevant for those with textured implants. See BIA-ALCL for more details, including the section on documents to share with doctors to help educate them.

2. Saline Implant Testing for Mold or Microbes

If you have saline implants, you can test the fluid for mold or microorganisms through labs like Mycometrics or Real Time. The cost is around $180 per implant, and results typically take 3-4 weeks. If you want your implants returned after testing, be sure to specify this with the lab in advance.

3. Genetic Testing Testing & MTHFR

Many women with BII test positive for MTHFR gene mutations, which can affect the body’s ability to detox. The The 23andMe genetic testing comes recommended for exploring this. Renowned explant surgeon, Dr. Lu-Jean Feng, has also spoken about the connection between MTHFR and breast implants.

4. ELISA/ACT Sensitivity Testing 

ELISA/ACT labs do not measure quantity or antibody levels, but instead test for sensitivities. They isolate white blood cells from your blood, place them in a lab plate, and expose them to various substances to observe immune cell responses. You cannot order direclty, you either need to go through betterlabtestsnow.com, call ELISA/ACT to find a lab nearby, or go through your practitioner. They offer a variety of tests that can measure sensitivity towards silicone, foods, fungi/molds, chemicals, and more. Read Elisa/ACT silicone allergy: Get Tested Before Breast Implant Surgery.

Their Silicone Hypersensitivity Panel is especially popular and tests for sensitivity to: Silicone, Silicates (silicon dioxide), Polyvinylpyrrolidone, Tin/stannous chloride, Titanium dioxide, Petroleum by products, Xylene, Toluene, Benzene, Latex, Phenol, Formaldehyde, Vinyl chloride, Green #5, Blue #2, Violet #2, Aspergillus niger, Candida albicans, Aluminum.

5. Silicon Serum/Plasma Test

This test measure the amount of elemental silicon (Si) in the blood, not silicone or silica. Silicone, a synthetic compound used in implants, is derived from silicon extracted from silica and further processed into polymers.

  • Research results have suggested “that elevations of serum silicon are seen in many women with silicone gel breast implants.”1
  • Three studies have shown that capsules from women with silicone gel breast implants had markedly elevated silicon levels compared to serum levels and to control breast tissue.2
  • The median level of silicon in 58 capsules from patients with silicone-gel breast implants was approximately 10,000x greater than that of control breast tissue.3
  • Four studies have shown that capsules from saline implants had elevated levels of silicon compared with control tissue, but their silicon levels were much lower than those of gel implants. “Although saline breast implants have been shown to shed silicone particles from the elastomeric envelope and others have suggested that silica could be released from the elastomer, our results clearly demonstrate that silicon levels in capsules around saline implants were elevated to a much lesser degree than those of gel implants.”5
  • A study on cadavers demonstrated measurable baseline silicon levels (varying from 0.2 to 45 ug/g tissue) – in fat, nipple, breast tissue, liver, spleen and axillary nodes – in 9 of 10 cadaveric patients who had not received breast implants. In contrast, 4 cadaveric patients who had received silicone breast implants had silicon levels in capsule and breast tissue, varying from 200 to 1,600 ug/g.6,7
  • Silicone is also used in other medical devices (Mirena IUD, penile implants, etc) and they have also had cases of health issues and documented elevated silicon serum.8,9 See here for a story on a woman with a silicone Mirena IUD who displays her elevated silicon serum test results and then retakes the test after detoxification and shows that the silicon levels are no longer detected.

6. Former Silicone Antibody & Detection Tests

Silicone antibody tests were once available in the 90s but have since been discontinued. Silicone has become a politically charged and controversial subject, and this appears to have impacted laboratory testing. Currently, there are no commercially available tests to detect silicone in the bloodstream. However, a 2016 research study explored a method for detecting silicone in the bloodstream of women with ruptured breast implants. Keep in mind that breast implants do not need to rupture for silicone to begin leaking, gel bleed can occur even with intact implants.

7. Heavy Metal Testing

For more precise testing, it is recommended to use ICP-MS lab analysis, which can be ordered usually through a toxicologist or by consulting your doctor. Each implant has a list of heavy metals used in its manufacturing, see list of heavy metals. Sharing this list with the testing provider can help tailor the analysis. The Carlson Company in Colorado is a toxicology lab that can do heavy metal and chemical testing of explanted capsule tissues.

A more affordable and commonly used method is the Hair Trace Mineral Analysis (HTMA), which can show mineral deficiencies and heavy metal levels from chronic toxic exposure. This can be done by a functional medicine or naturopathic doctor. Many in the breast implant illness community have worked with Pippa Galea for HTMAs.

A handful of heavy metals used in the manufacturing process are coming up in high levels in BII women and among them is copper. One theory links copper toxicity to silicone’s estrogenic properties. Silicone chemicals may act as xenoestrogens – synthetic compounds that mimic estrogen in the body – which can disrupt hormonal balance and contribute to estrogen dominance, a condition associated with higher copper levels and toxicity. Another theory suggests copper toxicity may stem from the high tin content in implants (see heavy metals). Tin can interfere with zinc absorption, and since zinc is the natural antagonist to copper, low zinc exacerbates copper buildup. Women with the MTHFR gene may also have impaired detoxification pathways, allowing heavy metals and toxins to accumulate. MTHFR has also been associated with high copper and therefore low zinc. Correcting this problem and balancing the ratio can be important. Excess copper is linked to symptoms such as adrenal stress, hypothyroidism (as the thyroid is highly sensitive to copper), hormonal imbalances, lowered immunity, anxiety, fatigue, depression, irritability, hyperactivity, and other issues.

8. Practitioner Support

Functional medicine, naturopathic, and environmental doctors are often better equipped to explore, interpret and apply the findings of these tests. They are typically more experienced in understanding the effects of chronic illness from toxic exposure.

9. Breast Ultrasound Without A Doctor’s Referral

If you don’t have health insurance or your doctor will not order an ultrasound, HerScan offers self-pay breast ultrasound services without a referral. Prices range from $195-$235 depending on the state. They move to different cities and states, it changes every month. You will need to check their link to see if and when they will be in a city near you. The scan includes a bilateral breast and axillary ultrasound, radiologist report, mailed results, and a CD if anything abnormal is found. Note: mammograms are less effective in detecting cancer for women with dense breast tissue or for detecting breast implant rupture. MRI is best but very expensive. Shared via Breast Implant Victim Advocacy (BIVA).

10. Lyme and Breast Implants

Silicone is both an immune and endocrine disruptor. As a foreign body, breast implants can create a foreign body reaction, which is the body’s inflammatory response to foreign material. This can lead to chronic immune system activation and contribute to immune dysregulation, interfering with lyme disease testing. Those previously diagnosed or undergoing lyme treatment may consider retesting 2-3 months post-explant, once the immune system begins to regulate. Dr. Lu-Jean Feng has spoken on this connection; lyme and breast implants.

11. Chronic Fatigue

Chronic fatigue is one of the most reported symptoms of BII. It may stem from various causes including anemia, low iron, low thyroid hormone, adrenal fatigue, reproductive hormone imbalances, low vitamin B12 and other nutritional deficiencies, chronic infections, impaired detoxification and an overloaded liver, heavy metal toxicity, mold exposure, allergies, intestinal dsybiosis, mitochondrial dysfunction, and excessive physical or emotional stress. Breast implants create artificial disturbance that disrupts the body’s natural systems.

12. Micronutrient Testing

Immune stress caused by implants can lead to vitamin, mineral, and antioxidant deficiencies. “SpectraCell’s Micronutrient tests measure the function of 35 nutritional components including vitamins, antioxidants, minerals and amino acids within our white blood cells.  Scientific evidence shows us that analyzing the white blood cells gives us the most accurate analysis of a body’s deficiencies.” Often times with BII, women are frustrated that generalized lab work appears normal, therefore deeper testing through micronutrient deficiency tests and/or hair mineral test analysis can help provide further insight on the imbalances.

International:

Australia

1. There is an innovative test that has the potential to identify any co-existing infections or other underlying causes, including other bacterial, viral, or fungal/mold infections. This test is called the NIIM Pathogen Blood Test. It has found silicone granulomas and chronic inflammation in a woman’s blood work.

2. The ELISA/ACT Silicone Hyperensitivity 19 Panel for lymphocyte (white blood cell) reactivity is internationally available via elisaact.com. They work through the practitioner Dr. Ritoo Chhabra in Castle Hill, Sydney.

3. Australia launched breast implant screening at the Integrated Breast Implant Check Clinic at Macquarie University Hospital.

Breast Implant Illness: A Way Forward (2019):

“A new breast implant check clinic commenced in Australia, is now scaling to 2 states and will provide an important low cost entry point for women with breast implant-related issues to be assessed both clinically and with imaging and/or pathology. These clinics will serve to capture patient, surgical, implant, and outcome data. They will also serve to standardize work up for patients with potential BII. These will include wide ranging blood screening for autoimmune disease markers (Table 3) and also collect patient-reported outcome measure data with validated instruments such as the BREAST-Q and modified BREAST-Q, as pertaining to cosmetic surgery. These patients will need to be followed up closely and for a period of ≥2 years to track their progress following explantation.”

‘Table 3. Suggested Blood Work for BII’ can be found by clicking on the article above and are listed here:

  • Full blood count
  • Urea electrolytes creatinine
  • Liver function tests
  • Thyroid funciton
  • CRP, ESR
  • Serum IgG, IgM
  • Iron, ferritin
  • Autoimmune disease markers
    • Antinuclear antibody, antineutrophil cytoplasmic antibody, anti-double strand DNA, anti-Sjogren’s syndrome A, anti-Sjogren’s syndrome B, rheumatoid factor, anti ribonucleic acid protein, Anti Sm, antiscleroderma antibodies, anti-TTG (tissue transglutaminase).

UK

Lymphocyte Sensitivity to Silicone is a test that can done by Acumen labs. Dr. Sarah Myhill and Dr. Damien Downing believe in breast implant illness and can help with testing and detox. In Dr. Myhill’s Silicone Breast Implants and Injections, under ‘Tests for Silicone Poisoning:’

“The most sensitive test available in this country to assess the reaction of white cells to silicone in the body is a lymphocyte chemical sensitivity (silicone) test. This just involves sending a blood sample to ACUMEN. This test does not tell us about the total load of silicone but whether or not the immune system has been activated agasint silicone. My clinical impression of tests done so far is that the worst affected women have the highest levels of sensitivity.”

Acumen Labs offers a wide array of unique tests that are not offered in the US, including mitochondrial tests to assess chronic fatigue. See Chronic fatigue syndrome and mitochondrial dysfunction.

Germany

In May 2020, a German woman successfully won a two year case for disability from breast implant illness. She was initially denied disability so she started a lawsuit.

In November 2019, the court appointed a psychiatrist who told her breast implant illness did not exist and said her illness was caused by social media.

The woman did not accept this decision and applied for a second review. In February 2020, she was assigned an environmental medicine specialist, Dr. med. Martin Schata in Düsseldorf, who ran extensive blood work. In May 2020, she got her new decision:

Chronic inflammation in multiple organs, chronic fatigue as a result of immune response to silicone breast implants. Disabled 60%.

For more information, visit the German BII website Krank Durch BrustImplantate and German FB group Krank Durch Brustimplantate – Breast Implant Illness DE. The woman involved in this case is also the founder of the first German BII FB support group.

Separate from the court case but relevant to the matter, she found a German lab called CellTrend that is doing a study on the harm of breast implants to the immune system. Their test for this is called POTS Diagnostic and costs around €467.

Final Thoughts:

Symptoms are your body’s way of indicating a reaction, it is not recommended to rely on lab work for “proof,” as this will be a waste of time and an unreliable approach. Many women who are very ill get disappointed by how their lab results do not reflect their sickness. Once you realize breast implants are contributing to your symptoms, it is best to respond with explantation in a timely manner to prevent further progression of illness.